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KMID : 0359320130530040225
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Korean Journal of Veterinary Research
2013 Volume.53 No. 4 p.225 ~ p.230
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Alternatively activated M2 macrophages increase in early stages of experimental autoimmune myocarditis in Lewis rats
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Oh Han-Seul
Ahn Mee-Jung
Matsumoto Yoh
Shin Tae-Kyun
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Abstract
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To better understand the role of macrophages in early stages of experimental autoimmune myocarditis (EAM), we compared the expression of inducible nitric oxide synthase (iNOS) and arginase-1, markers for classically activated M1 and alternatively activated M2 macrophages, respectively, in the hearts of EAM-affected and control rats. Immunohistochemical evidence revealed that both iNOS-positive and arginase 1-positive macrophages were found in EAM lesions, while some cells were co-localized with both markers. This finding suggests that the increased level of arginase-1, which is partly from M2 macrophages, contributes to the modulation of EAM, possibly through the reduction of nitric oxide in the lesion.arginase-1, experimental autoimmune myocarditis, inducible nitric oxide synthase, macrophage
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KEYWORD
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arginase-1, experimental autoimmune myocarditis, inducible nitric oxide synthase, macrophage
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